Setubal is with only one point already out of this cup. The coach announced that he will make some changes
https://www.abola.pt/Clubes/Noticias/Ver/765863/474
If you understand purtugese language you can watch summary of pre match conference. Maybe there are some more details.
https://vfc.pt/2018/12/27/oportunidade-para-jogadores-menos-utilizados/
Braga is pratically in next round. A draw is enough. Even if they lose, they most lose very high due to their good goal difference. I expect Braga to make also some changes, but coach confirmed 1st team squad with all stars.
https://scbraga.pt/vitoria-fc-x-sc-braga-convocados-27dez/
Also I read between the lines that Braga wants to get a postive result after the heavy 2:6 against Benfica.
https://scbraga.pt/vamos-dar-uma-grande-resposta/